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Paolo Avesani presents a poster at OHBM 2015

News date: 
Monday, 15 June, 2015

The Organization for Human Brain Mapping (OHBM) is the primary international organization dedicated to using neuroimaging to discover the organization of the human brain. This year the yearly meeting took place from June 14 to June 18 in Honolulu, Hawaii. Paolo Avesani' poster presented joint work with Thien Bao Nguyen, Nusrat Sharmin, Nivedita Agarwal, Mark Bromberg, Lubdha Shah and Emanuele Olivetti. The poster was entitled "White-Matter Alignment Across Subjects By Tractography Mapping".

Current neuroscientific analyses of white matter tractography data are limited to intra-subject comparisons, because it is difficult to operate a quantitative analysis across subjects. The common approach to align deterministic tractographies is indirect, i.e. based on the registration of volumetric images. The transformation resulting from registering volumetric images, such as T1 or fractional anisotropy (FA), to a standard space, is applied to the streamlines of the tractography in the native space. More recently, an alternative approach has been proposed based on the idea of directly registering streamlines rather than voxels. According to this view, affine transformations are computed to minimize the misalignment among the trajectories of the streamlines. The authors proposed an innovative method to align tractographies, that does not require transformation of the data at all. It is based on finding the correspondence between streamlines across subjects, i.e. which streamline of the tractography of one subject, corresponds to which streamline of the tractography of the other subject. In other words, aligning the tractographies of two subjects is regarded as a problem of finding the mapping between two sets of streamlines.